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Histamine produces increased vascular permeability, causing fluid to escape from capillaries into tissues, which leads to the classic symptoms of an allergic reaction — a runny nose and watery eyes. Antihistamines suppress the histamine-induced wheal response (swelling) and flare response (vasodilation) by blocking the binding of histamine to its receptors or reducing histamine receptor activity on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells.Itching, sneezing, and inflammatory responses are suppressed by antihistamines that act on H1-receptors.Allergy medication such as Benadryl and Chlor-Trimeton cause drowsiness, dry mouth, dizziness, blurred vision, nausea, and restlessness.
The authors of the American College of Chest Physicians Updates on Cough Guidelines (2006) recommend that, for cough associated with the common cold, first-generation antihistamine-decongestants are more effective than newer, non-sedating antihistamines.
First-generation antihistamines include diphenhydramine (Benadryl), carbinoxamine (Clistin), clemastine (Tavist), chlorpheniramine (Chlor-Trimeton), and brompheniramine (Dimetane).
Antihistamines that target the histamine H receptors in the upper gastrointestinal tract, primarily in the stomach.
Histamine receptors exhibit constitutive activity, so antihistamines can function as either a neutral receptor antagonist or an inverse agonist at histamine receptor.
Many of the brand names above are for these combination medicines.
These are meant to treat many symptoms at the same time.
The effects of these drugs on mood, daytime sleepiness, and some measures of sleep quality were assessed before and after one month of treatment.
The researchers compared the effects of all drugs on daytime sleepiness and mood, noting that very few studies so far have made these comparisons.
Allergy sufferers have long faced a no-win situation with traditional antihistamine medications: sneeze and itch your way through seasonal allergies or take antihistamines and live in a fog instead.
Antihistamines stop allergy symptoms by reducing or blocking histamines—chemicals the body releases in response to an allergic trigger.
Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic action but are not true antihistamines.Tags: Adult Dating, affair dating, sex dating